Drosha Recombinant Rabbit mAb
Product Specifications
Background
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976
Swiss Prot
Q9NRR4
Reactivity
Human
Immunogen
A synthetic peptide of human Drosha
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
159 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of extracts from HeLa cells using db12517 at 1:1000.
Host or Source
Rabbit
Available Sizes
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