Cullin 4A/B Recombinant Rabbit mAb

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Cullin 4A/CUL-4A+Cullin 4B/CUL-4B in Jurkat, C6, CHO-K1 cell lysates using Cullin 4A/CUL-4A+Cullin 4B/CUL-4B antibody (1:500 diluted) .