Bag3 Recombinant Rabbit mAb
Product Specifications
Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
BIS; MFM6; BAG-3; CAIR-1
Swiss Prot
O95817
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human Bag3
Conjugation
Unconjugated
Applications
WB, ICC/IF, FC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
80 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Bag3 in C6,3T3, Hela cell lysates using Bag3 antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
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