PPP4C Recombinant Rabbit mAb
Product Specifications
Background
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
PP4; PPX; PP-X; PP4C; PPH3; PPP4
Swiss Prot
P60510
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human PPP4C
Conjugation
Unconjugated
Applications
WB, IHC, FC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of PP-X in K562, C6,3T3, Hela cell lysates using PP-X antibody (1:1000 diluted) .
Host or Source
Rabbit
CAS Number
9000-83-3
Available Sizes
Curated Selection
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