BRCC36 Recombinant Rabbit mAb
Product Specifications
Background
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
C6.1A; BRCC36; CXorf53
Swiss Prot
P46736
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human BRCC36
Conjugation
Unconjugated
Applications
WB, FC, IP
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
36 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of BRCC36 in Rat Brain, C6,3T3, Hela cell lysates using BRCC36 antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
Curated Selection
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