Cip4 Recombinant Rabbit mAb
Product Specifications
Background
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity) . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
STP; CIP4; HSTP; STOT; TRIP-10
Swiss Prot
Q15642
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human Cip4
Conjugation
Unconjugated
Applications
WB, IHC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
80 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Cip4 in 3T3 cell lysates using Cip4 antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
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