ALKBH5 Recombinant Rabbit mAb
Product Specifications
Background
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Can also demethylate N6-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105) . Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736) . Required for spermatogenesis (By similarity) .
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
ABH5; OFOXD; OFOXD1
Swiss Prot
Q6P6C2
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human ALKBH5
Conjugation
Unconjugated
Applications
WB, IHC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
44 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of extracts from HeLa cells using it at 1:1000.
Host or Source
Rabbit
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6233205-01 0.1 mL
HECTD1 (E3 Ubiquitin-protein Ligase HECTD1, E3 Ligase for Inhibin Receptor, EULIR, HECT Domain-containing Protein 1, KIAA1131) (MaxLight 750)
Sign In for Pricing
View Details MBS6233205-02 5x 0.1 mL
HECTD1 (E3 Ubiquitin-protein Ligase HECTD1, E3 Ligase for Inhibin Receptor, EULIR, HECT Domain-containing Protein 1, KIAA1131) (MaxLight 750)
Sign In for Pricing
View Details MBS1106439 Inquire
Recombinant Pseudomonas putida Phosphoenolpyruvate carboxykinase [ATP] (pckA), partial
Sign In for Pricing
View Details 
45581121 3x 1.0µg DNA
SSX8 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details