Axin 2 Recombinant Rabbit mAb
Product Specifications
Background
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
AXIL; ODCRCS
Swiss Prot
Q9Y2T1
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human Axin 2
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
94 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Axin 2 in K562, C6,3T3, Hela cell lysates using Axin 2 antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
Curated Selection
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