XIAP Recombinant Rabbit mAb
Product Specifications
Background
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3
Swiss Prot
Q60989
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human XIAP
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:1000
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
53 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of XIAP in K562, Rat Brain,3T3 cell lysates using XIAP antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
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