Phospho-MLKL (Ser345) Recombinant Rabbit mAb
Product Specifications
Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
9130019I15Rik
Swiss Prot
Q9D2Y4
Reactivity
Mouse
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser345 of mouse MLKL
Conjugation
Unconjugated
Applications
WB, IP
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Host or Source
Rabbit
Available Sizes
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