Phospho-IRE1 (Ser724) Recombinant Rabbit mAb
Product Specifications
Background
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
IRE1b; IRE2p; hIRE2p; IRE1-BETA
Swiss Prot
O75460
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:1000-1:5000
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of IRE1 (Phospho-Ser724) in K562 cell lysates using IRE1 (Phospho-Ser724) antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
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