Phospho-p130 (Thr986) Recombinant Rabbit mAb
Product Specifications
Background
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
Rb2; P130
Swiss Prot
Q08999
Reactivity
Human, Mouse
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130
Conjugation
Unconjugated
Applications
WB, FC, IP
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
130 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Phospho-Rb2 p130 (Thr986) in K562 cell lysates using Phospho-Rb2 p130 (Thr986) antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
Curated Selection
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