Phospho-Rb (Thr252) Recombinant Rabbit mAb
Product Specifications
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1
Swiss Prot
P06400
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Thr252 of human Rb
Conjugation
Unconjugated
Applications
WB, IHC
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Rb (phospho-Thr252) in HL-60, U2OS, C6 using Rb (phospho-Thr252) antibody (1:1000 diluted)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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