Phospho-TrkA (Tyr490) /TrkB (Tyr516) /TrkC (Tyr516) Recombinant Rabbit mAb
Product Specifications
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
OBHD; TRKB; trk-B; GP145-TrkB
Swiss Prot
Q16620
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Tyr516 of human TrkB
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:1000
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
140 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Phospho-TrkA (tyr490) /TrkB (Tyr516) in K562, C6,3T3 cell lysates using Phospho-TrkA (tyr490) /TrkB (Tyr516) antibody (1:1000 diluted) .
Host or Source
Rabbit
CAS Number
9000-83-3
Available Sizes
Curated Selection
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