Phospho-AMPK alpha 1 (Ser496) Recombinant Rabbit mAb
Product Specifications
Background
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
AMPK; AMPKa1
Swiss Prot
Q13131
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser496 of human AMPK alpha 1
Conjugation
Unconjugated
Applications
WB, ICC/IF, IP
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
64 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of AMPK alpha 1 (phospho-Ser496) in Ramos cell lysates using AMPK alpha 1 (phospho-Ser496) antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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