Phospho-EIF2S1 (Ser51) Recombinant Rabbit mAb
Product Specifications
Background
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161) . The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]) .[supplied by OMIM, Feb 2010]
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha
Swiss Prot
P05198
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser51 of human EIF2S1
Conjugation
Unconjugated
Applications
WB, IHC
Purity
Affinity Purification
Modification
Phosphorylated
Molecular Weight
36 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of Phospho-eIF2A (Ser51) in K562, C6,3T3, Hela cell lysates using Phospho-eIF2A (Ser51) antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb3086713 200 µL
Fruit fly Unc13B-protein Rabbit Polyclonal Antibody (Fluoro550)
Sign In for Pricing
View Details