RB1 mouse monoclonal antibody
Product Specifications
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
OSRC; p105-Rb; pp110; PPP1R130; pRb; RB
Swiss Prot
P06400
Reactivity
Human, Mouse, Rat
Immunogen
Human recombinant protein fragment corresponding to amino acids 309-590 of human RB1 (NP_000312) produced in E.coli.
Conjugation
Unconjugated
Applications
IHC, WB
Dilution
WB 1:2000, IHC 1:500
Purity
The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG2b
Host or Source
Mouse
Available Sizes
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