CCT5 polyclonal antibody

Product Specifications

Background

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC) . This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP) . Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

CCT5; CCT-epsilon; CCTE; HEL-S-69; PNAS-102; TCP-1-epsilon

Swiss Prot

P48643

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human CCT5 (NP_036205.1) .

Conjugation

Unconjugated

Applications

Dilution

WB,1:500 - 1:2000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .