Acetyl-DNMT1-K1127/K1129/K1131/K1133 polyclonal antibody
Product Specifications
Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI; DNMT1
Swiss Prot
P26358
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic acetylated peptide around K1127 & K1129 & K1131 & K1133 of human DNMT1 (NP_001124295.1) .
Conjugation
Unconjugated
Applications
IHC, IF/ICC
Dilution
IHC,1:50 - 1:100|IF/ICC,1:50 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Acetylated
Molecular Weight
Refer to figures
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Acetylated Antibodies
Applications Notes
Immunofluorescence analysis of C6 cells using Acetyl-DNMT1-K1127/K1129/K1131/K1133 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Host or Source
Rabbit
Available Sizes
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