SSCA1/SerpinB3 polyclonal antibody

Product Specifications

Background

Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. It may act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. It also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH (2) -terminal kinase (JNK1) .

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

SERPINB3; HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; SSCA1; T4-A; serpin B3

Swiss Prot

P29508

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human SSCA1/SerpinB3 (NP_008850.1) .

Conjugation

Unconjugated

Applications

WB, IF/ICC

Dilution

WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .