ID3 polyclonal antibody
Product Specifications
Background
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ID3; HEIR-1; bHLHb25
Swiss Prot
Q02535
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ID3 (NP_002158.3) .
Conjugation
Unconjugated
Applications
WB IHC IF/ICC
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200 IF/ICC: 1:50~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
13KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ID3 polyclonal antibody detects endogenous levels of ID3 protein.
Applications Notes
Western blot analysis of ID3 expression in Hela (A), A549 (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Curated Selection
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