Prolyl hydroxylase PHD1 (EGLN2) polyclonal antibody

Product Specifications

Background

The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

EGLN2; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1

Swiss Prot

Q96KS0

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human hydroxylase PHD1 (EGLN2) ) (NP_444274.1) .

Conjugation

Unconjugated

Applications

WB, IP

Dilution

WB,1:500 - 1:2000|IP,1:20 - 1:50

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .