[KO Validated] GRK2 polyclonal antibody

Product Specifications

Background

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

GRK2; ADRBK1; BARK1; BETA-ARK1

Swiss Prot

P25098

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human GRK2 (NP_001610.2) .

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB,1:500 - 1:2000|IHC,1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .