CPEB3 polyclonal antibody

Product Specifications

Background

Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE, a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity. Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity. When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

CPEB3

Swiss Prot

Q8NE35

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human CPEB3 (NP_055727.3) .

Conjugation

Unconjugated

Applications

WB, IHC, IF/ICC

Dilution

WB,1:200 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .