CPEB3 polyclonal antibody
Product Specifications
Background
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE, a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity. Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity. When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity.
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CPEB3
Swiss Prot
Q8NE35
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CPEB3 (NP_055727.3) .
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC
Dilution
WB,1:200 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
75kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Polyclonal Antibodies
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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