β-arrestin1 polyclonal antibody

Product Specifications

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

ARRB1; ARB1; ARR1

Swiss Prot

P49407

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human β-arrestin1 (NP_004032.2) .

Conjugation

Unconjugated

Applications

WB, IHC, IF/ICC, IP

Dilution

WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:20 - 1:100|IP,1:50 - 1:100

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .