TJP2 polyclonal antibody

Product Specifications

Background

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

TJP2; C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2

Swiss Prot

Q9UDY2

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human TJP2 (NP_004808.2) .

Conjugation

Unconjugated

Applications

WB, IP

Dilution

WB,1:500 - 1:2000|IP,1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .