CD161 (3F8) monoclonal antibody
Product Specifications
Background
Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. T cells bearing natural killer receptors (NKRs) such as CD94 and CD161 are present in psoriasis. CD161 mediates NK cell activation and functions as an activating receptor. CD161 is a prototypic marker of NK cells, although it is also found on a subset of CD8+ T cells. The expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector T cells that are expanded in vivo after antigenic activation leading to extensive proliferation. The transcription, mRNA accumulation, and surface expression of CD161, a molecule involved in triggering cytotoxicity, is specifically upregulated by IL-12.
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161
Swiss Prot
Q12918
Reactivity
Rat
Immunogen
Synthetic peptide, corresponding to amino acids of Human CD161.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 25 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD161 (3F8) mAb detects endogenous levels of CD161 protein.
Applications Notes
Western blot (WB) analysis of CD 161 (NKR-PIA) mAb at 1:2000 dillution Lane1:The Peripheral blood lysate of Rat (40μg) Lane2:The Liver tissue lysate of Rat (40μg)
Host or Source
Mouse
CAS Number
9007-83-4
Available Sizes
Curated Selection
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