CD11B (L1) monoclonal antibody
Product Specifications
Background
Integrin αM, also designated complement component receptor-3 α, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin αM combines with the Integrin β2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3) . Integrin αM/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b; ITGAM; CD11B; CR3A; Integrin αM; CR-3α; CR3α
Swiss Prot
P11215
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human CD11B (630aa-1104aa) .
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas, Tumor-Infiltrating Immune Cell Marker Guide
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 170 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD11B (L1) mAb detects endogenous levels of CD11B protein.
Applications Notes
Western blot (WB) analysis of CD11B (L1) mAb at 1:500 dilution Lane1:Myla2059 whole cell lysate (30ug) Lane2:HuT78 whole cell lysate (30ug) Lane3:K562 whole cell lysate (30ug) Lane4:The Spleen tissue lysate of Rat (40ug) Lane5:RAW264.7 whole cell lysate (40ug) Lane6:THP-1 whole cell lysate (40ug)
Host or Source
Mouse
CAS Number
9007-83-4
Available Sizes
Curated Selection
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