RanBP9 monoclonal antibody

Product Specifications

Background

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B.

CAS Number

9007-83-4

Structure Composition

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

BPM-L; BPM90; Ran-binding protein M; RanBPM; RanBP7; BPM-L; BPM90; RANBPM; RanBP7

Swiss Prot

Q96S59

Reactivity

Human

Immunogen

Recombinant full length Human RanBP9.

Conjugation

Unconjugated

Applications

WB IP ICC

Dilution

WB: 1:1000 ICC: 1:100~300 IP: 1:50~100

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .