Hexokinase-2 (N-term) monoclonal antibody

Product Specifications

Background

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Hexokinase 2; Hexokinase2; Hexokinase type II; HK II; Muscle form hexokinase; HK2

Swiss Prot

P52789

Reactivity

Human, Rat

Immunogen

Synthetic peptide, corresponding to amino acids N-terminus of Human Hexokinase-2.

Conjugation

Unconjugated

Related Pathways

Warburg Effect, Insulin &Glucose Signaling, Glutamine Metabolism

Applications

WB FC

Dilution

WB: 1:1000 FC: 1:50~100

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .