Sox2 monoclonal antibody
Product Specifications
Background
SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX 2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Transcription factor SOX-2
Swiss Prot
P48431
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human Sox2.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas, ESC Pluripotency and Differentiation Signaling Pathway
Applications
WB ICC FC
Dilution
WB: 1:1000 ICC: 1:50~200 FC: 1:50~100
Purity
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
Predicted band size:35KDa Observed band size:35KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
This antibody detects endogenous levels of Sox2 and does not cross-react with related proteins
Applications Notes
Western blot detection of Sox2 antibody in F9 cell lysates using Sox2 antibody (1:1000 diluted) .
Host or Source
Mouse
Available Sizes
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