CHD3 (C-terminus) monoclonal antibody

Product Specifications

Background

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Chromodomain-helicase-DNA-binding protein 3; CHD-3; Hzfh; Zinc finger helicase; Mi2-alpha; ATP-dependent helicase CHD3

Swiss Prot

Q12873

Reactivity

Human

Immunogen

Synthetic peptide, corresponding to the C-terminus of Human CHD3.

Conjugation

Unconjugated

Related Pathways

ATP-Dependent Chromatin Remodeling Complexes, DNA Methylation

Applications

WB IHC FC

Dilution

WB: 1:1000 IHC: 1:500 FC: 1:50~100

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .