UHRF1 (N-terminus) monoclonal antibody

Product Specifications

Background

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

CAS Number

9007-83-4

Structure Composition

Mouse IgG2b, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Np95; hNP95; ICBP90; RNF106; FLJ21925; MGC138707; E3 ubiquitin-protein ligase UHRF1; Nuclear protein 95; HuNp95; hNp95; RING finger protein 106

Swiss Prot

Q96T88

Reactivity

Human, Mouse

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human UHRF1.

Conjugation

Unconjugated

Related Pathways

DNA Methylation

Applications

WB ICC

Dilution

WB: 1:1000 ICC: 1:50~200

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .