Tet1 (C-term) polyclonal antibody
Product Specifications
Background
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC) . Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Methylcytosine dioxygenase TET1; CXXC-type zinc finger protein 6; Ten-eleven translocation 1 gene protein homolog; Cxxc6; Kiaa1676
Swiss Prot
Q3URK3
Reactivity
Mouse
Immunogen
This mouse Tet1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1845-1879 amino acids from the C-terminal region of mouse Tet1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 219 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Tet1 (C-term) polyclonal antibody detects endogenous levels of Tet1 protein.
Applications Notes
Anti-Tet1 Antibody (C-term) at 1:2000 dilution + F9 whole cell lysates Lysates/proteins at 20 µg per lane.
Host or Source
Rabbit
Available Sizes
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