SERPINA6 polyclonal antibody

The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and tissue development. SerpinA6, also known as CBG or Transcortin, is a 405 amino acid α-globulin secreted protein that belongs to the serpin family. Synthesized in the liver and present in glycocorticoid responsive cells, SerpinA6 functions as the primary transport protein for progestins and glucorticoids within the blood. Additionally, SerpinA6 has corticosteroid-binding properties through which it can regulate the physiological binding of serum cortisol within the cell. Defects in the gene encoding SerpinA6 are the cause of corticosteroid-binding globulin deficiency (CBG deficiency), a rare disorder characterized by reduced corticosteroid-binding rates that result in hypo/hypertension and muscle fatigue.

CBG; CBG_HUMAN; corticosteroid binding globulin; Corticosteroid-binding globulin; serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; Serpin A6; serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; Serpina6; Transcortin

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .