PTN polyclonal antibody

Pleiotrophin? (PTN) also known as?heparin-binding brain mitogen? (HBBM) or?heparin-binding growth factor 8? (HBGF-8) or?neurite growth-promoting factor 1? (NEGF1) or?heparin affinity regulatory peptide? (HARP) or?heparin binding growth associated molecule? (HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

HARP; HB-GAM; HBBM; HBGAM; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; heparin affin regulatory protein; Heparin binding growth associated molecule; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; Heparin-binding brain mitogen; heparin-binding growth associated molecule; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neurite outgrowth-promoting factor 1; NEGF1; Neurite Growth Promoting Factor 1; Neurite outgrowth-promoting factor, heparin-binding; OSF-1; OSF1; Osteoblast-specific factor 1; osteoblast-specific factor; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) ; Pleiotrophin; PTN; PTN_HUMAN

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .