Cytokeratin 15 polyclonal antibody
Product Specifications
Background
Cytokeratin 15 is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Keratin, type I cytoskeletal 15; Cytokeratin-15, Short name=CK-15; Keratin-15; Short name=K15; KRT15; KRTB; Keratin 15; CK15; CK 15; Keratin15
Swiss Prot
P19012
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human Cytokeratin 15.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 49 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cytokeratin 15 polyclonal antibody detects endogenous levels of Cytokeratin 15 protein.
Applications Notes
Western blot analysis of extracts of Mouse thymus tissue lysate, using Cytokeratin 15 antibody.
Host or Source
Rabbit
Available Sizes
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