VCL polyclonal antibody
Product Specifications
Background
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CMD1W; CMH15; HEL114; MV; MVCL
Swiss Prot
P18206
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human VCL
Conjugation
Unconjugated
Related Pathways
Tumor Angiogenesis
Applications
WB IHC
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 130 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
VCL polyclonal antibody detects endogenous levels of VCL protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using VCL antibody.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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