MYL6B polyclonal antibody

MYL6B (Myosin light chain 6B) is a heavy chain regulator found in smooth muscle and non-muscle Myosin complexes. Three general classes of Myosin have been cloned: smooth muscle myosins, striated muscle myosins and non-muscle myosins. Contractile activity in smooth muscle is regulated by the calcium/calmodulin-dependent phosphorylation of myosin light chain by myosin light chain kinase. Myosin heavy chains are encoded by the MYH gene family and have Actin-activated ATPase activity which generates the motor function of Myosin. Although it contains three of the EF-hand domains common to Actin and other Myosin regulating proteins, MYL6B does not bind calcium during contraction. It is primarily found in a hexamer consisting of four light chains and two heavy chains.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .