SUCLA2 polyclonal antibody

SUCLA2 (succinate-CoA ligase, ADP-forming, beta subunit), also known as A-BETA, SCS-betaA or renal carcinoma antigen NY-REN-39, is a 463 amino acid mitochondrial matrix enzyme that belongs to the succinate/malate CoA ligase beta subunit family. Widely expressed, SUCLA2 dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. Defects in SUCLA2 may be involved in a group of autosomal recessive disorders known as Mitochondrial DNA depletion syndromes (MDSs) that are characterized by a decrease in mitochondrial DNA copy numbers in affected tissues.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .