Caspase-7 p20 (D198) polyclonal antibody

A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly (ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks.

Apoptosis related cysteine peptidase; Apoptosis Related Cysteine Protease; Apoptotic protease Mch-3; Apoptotic Protease MCH3; CASP 7; CASP-7; CASP7; Caspase-7 subunit p11; Caspase7; CMH 1; CMH-1; CMH1; ICE LAP3; ICE like Apoptotic Protease 3; ICE-LAP3; ICE-like apoptotic protease 3; MCH3

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Caspase-7 p20 (D198) polyclonal antibody detects endogenous levels of the large fragment of caspase-7 resulting from cleavage at Asp198. The antibody does not cross-react with full length caspase-7 or with other caspases.