IL13 polyclonal antibody

Interleukin-13, or IL-13, is a pleiotropic cytokine that exhibits 30% sequence identity with IL-4 and shares many of the same biological activities. Like IL-4, IL-13 affects monocytes, macrophages and B cells by upregulating the expression of CD23 and MHC proteins, and downregulating the expression of CD14. Both IL-4 and IL-13 are secreted by activated T lymphocytes and are powerful regulators of inflammation. Both inhibit the secretion of proinflammatory cytokines and chemokines from activated monocytes and stimulate the expression of IgE on activated B cells. IL-13 contains five Cysteine residues and multiple N-linked glycosylation sites and has been reported to inhibit the production of IL-2 in natural killer cells. IL-13 cDNA encodes a 131 amino acid precursor with a 20 amino acid signal peptide which is cleaved to generate a mature protein.

Allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma) ; IL 13; IL-13; Il13; IL13; Interleukin 13; Interleukin-13; MGC116786; MGC116788; MGC116789; NC30; P600

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .