NOS1 (phospho-S1417) polyclonal antibody
Product Specifications
Background
Nitric Oxide Synthase (NOS) catalyzes the formation of nitric oxide (NO) and citruline from L-arginine, oxygen and cofactors. Three family members have been characterized: neuronal NOS (nNOS), which is found primarily in neuronal tissue; inducible NOS (iNOS), which is induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system; and endothelial NOS (eNOS), which is expressed in blood vessels. NO is a messenger molecule with diverse functions throughout the body including the maintenance of vascular integrity, homeostasis, synaptic plasticity, long-term potentiation, learning, and memory.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Nitric oxide synthase, brain; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOS; NOS1
Swiss Prot
P29475
Reactivity
Human
Immunogen
Synthetic phosphopeptide derived from human NOS1 around the phosphorylation site of Serine 1417
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 160 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-NOS1 (S1417) pAb detects endogenous levels of p-NOS1 (S1417) protein only when phosphorylated at Ser1417.
Applications Notes
Western blot (WB) analysis of p-NOS1 (S1417) pAb at 1:500 dilution Lane1:PC3 whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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