DPP7 polyclonal antibody
Product Specifications
Background
Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPP7 (dipeptidyl-peptidase 7), also known as DPP2, DPPII or QPP (quiescent cell proline dipeptidase), is expressed in quiescent lymphocytes and localizes to lysosomes. In response to calcium release, DPP7 can be secreted in its active form. DPP7 exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. DPP7 is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Dipeptidyl peptidase 2; Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; DPP II; Quiescent cell proline dipeptidase; DPP7; DPP2; QPP
Swiss Prot
Q9UHL4
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 430-480 of Human DPP7.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
DPP7 polyclonal antibody detects endogenous levels of DPP7 protein.
Applications Notes
Western blot (WB) analysis of DPP7 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:U-87MG whole cell lysate (40ug)
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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