CD272 polyclonal antibody
Product Specifications
Background
B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272; BTLA
Swiss Prot
Q7Z6A9
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 130-180 of Human BTLA.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 32 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD272 polyclonal antibody detects endogenous levels of CD272 protein.
Applications Notes
Western blot (WB) analysis of CD272 polyclonal antibody at 1:500 dilution Lane1:HCT116 whole cell lysate (20ug) Lane2:L02 whole cell lysate (20ug) Lane3:C6 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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