BRE polyclonal antibody

The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of the DNA damage response and DNA repair. BRCA1 protein forms at least three distinct complexes (BRCA1 A, B, and C) with other DNA repair proteins, and these interactions are vital for regulation of BRCA1 function. The BRCA1 A complex includes Rap80, BRCC36, Abraxas, MERIT40/NBA1, and BRE/BRCC45 and functions in G2/M phase checkpoint control. MERIT40 and BRE maintain the stability of both the BRCA1 A complex and the cytoplasmic BRISC complex, which contains BRCC36 and ABRO1 but not BRCA1. Researchers have shown that the expression level of BRE is related to patient survival in breast cancer, and it may predict a favorable outcome in acute myeloid leukemia (AML) . Studies have also shown that BRE is overexpressed in human hepatocellular carcinoma and that overexpression of BRE can cause resistance to apoptotic signaling and promote tumor growth.

BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein; BABAM2; BRCC45; BRE

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of BRE polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate (40ug) Lane2:HCT116 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:PC12 whole cell lysate (20ug) Lane5:CT26 whole cell lysate (40ug)