PPP1R16B polyclonal antibody

Protein phosphatase 1 regulatory inhibitor subunit 16B, regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956) . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873) . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity) . Protects the endothelial barrier from lipopolysaccharide (LPS) -induced vascular leakage (By similarity) . Involved in the regulation of endothelial cell filopodia extension (By similarity) . May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956) . Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956) . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087) . Involved in the dephosphorylation of EEF1A1 (PubMed:26497934) .

Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP; PPP1R16B; ANKRD4; KIAA0823

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of PPP1R16B polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:C6 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug)