PNPLA6 polyclonal antibody

Product Specifications

Background

Neuropathy target esterase (NTE) is a member of a newly discovered protein family, with a domain conserved through evolution. It is an integral membrane protein present in all neurons and in some non-neural cell types of vertebrates. NTE is important in neural development and has the capacity to hydrolyse esters. It is important in the cell-signalling pathway controlling interactions between neurons and accessory glial cells in nervous system development. NTE can be modified by organophosphates, which can cause neuropathy (characterized by axonal degeneration) in humans. NTE loss can lead to prominent neuronal pathology in the thalamus amd hippocampus and can also lead to defects in the cerebellum.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6; PNPLA6; NTE

Swiss Prot

Q8IY17

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding Human PNPLA6.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 150 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

PNPLA6 polyclonal antibody detects endogenous levels of PNPLA6 protein.

Applications Notes

Western blot (WB) analysis of PNPLA6 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:COS-7 whole cell lysate (40ug) Lane3:C6 whole cell lysate (40ug) Lane4:MEF whole cell lysate (40ug)