IKZF2 polyclonal antibody
Product Specifications
Background
Helios (Ikaros family zinc finger 2, IZKF2) is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family proteins. In the hematopoietic system, Helios expression is restricted to T cells and early hematopoietic progenitors. In regulatory T cells, expression of Helios contributes to an anergic phenotype by binding to the IL-2 promoter and suppressing IL-2 transcription. In addition, alteration of the corresponding Helios gene IZKF2 is one hallmark of low-hypodiploid acute lymphoblastic leukemia.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Zinc finger protein Helios; Ikaros family zinc finger protein 2; IKZF2; HELIOS; ZNFN1A2
Swiss Prot
Q9UKS7
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding Human IKZF2.
Conjugation
Unconjugated
Related Pathways
Immune Cell Signaling
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 85 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IKZF2 polyclonal antibody detects endogenous levels of IKZF2 protein.
Applications Notes
Western blot (WB) analysis of IKZF2 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:PC12 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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